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Reasons for the Label Expansion The FDAs new approval is based on the cardiovascular outcomes from the SELECT trial

One unexpected serious adverse reaction occurred in a NAC-treated patient caused by an erroneous iv infusion rate (1.5g-loading dose-15 min followed by 7.5 g delivered over 3h15min instead of 4 h), causing chest tightness, despite stable vital signs, which was resolved by corticosteroids and discontinuation of iv NAC

Consequently, individuals do not exhibit warning signs of overdose, such as vomiting or loss of consciousness, allowing blood alcohol concentration (BAC) to reach lethal levels unnoticed

1 But these drugs also come with a high price tag

While both peptides bind to the GHRH receptor, their different structures and durations of action could potentially influence downstream signaling cascades in slightly different ways