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After the metabolite dataset was scaled by log 2 transformation and z-score normalization algorithm, data was randomly split into the training dataset and the testing dataset

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36,37 As a result of the activation of stellate cells and a subsequent enhancement in collagen and extracellular matrix synthesis, the space of Disse becomes thickened, so that capillarization develops and the normal fenestrated architecture of the sinusoidal endothelium is lost