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Reflux is always position-dependentwhen lying down, such as in bed or on the sofa, gravity has less effect, and fluid tends to rise into the esophagus

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Given their direct and indirect control of post-prandial nutrient uptake and demonstrated translational relevance for the treatment of type 2 diabetes, malabsorption and cardiometabolic disease, there is significant interest in the locally engaged circuits mediating these metabolic effects