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References Pullar JM, Carr AC, Vissers MCM
K110-glutarylation and lipoyl glutarylation were detected in GCDH null cells, but the effects were variable, and GCDH depletion did not alter lipoylation or lysine glutarylation by immunoblot (Supplementary Figs
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At 4mg, rates ranged from 18% to 36%
In acromegaly, the somatotropinoma in the anterior pituitary produces excessive amounts of growth hormone (GH)
However, regularly new mutations and variants of unknown significance (VUS) are identified, requiring functional studies such as enzyme activity measurements or cellular flux analysis for confirmation of the diagnosis and characterization [51]
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