Avoid repeatedly removing and replacing semaglutide in the refrigerator, as temperature cycling stresses the peptide bonds
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These drug supply issues are a great opportunity to have patient management reviews, emphasise principles around healthy lifestyle, and review therapies including prescribing options or even de-prescribing if possible. Alternative treatment options suggested by the RACGP include: Liraglutide, which is administered once daily and has evidence of cardiovascular benefit, but is not subsidised by PBS SGLT-2 inhibitors, especially in those who also have cardiovascular disease, multiple cardiovascular risk factors and/or kidney disease DPP-4 inhibitors, which may be useful in those who do not have cardiovascular disease, multiple cardiovascular risk factors or kidney disease, and are unable to achieve optimal blood glucose levels Sulphonylureas or insulin (initiation or titrated doses), but these may lead to risks for hypoglycaemia and weight gain The twice daily exenatide (Byetta) is not recommended as a potential substitute, as it has been discontinued and is also no longer available
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For short trips (under 21 days), unopened tirzepatide pens or syringes can be transported at room temperature without additional cooling, provided ambient temperatures remain below 86F (30C)
Most people start feeling relief within 15-45 minutes after we start the infusion
