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By contrast, the G6PD-Sumare variant exhibited a notable reduction in growth (86% of WT, P = 6.736 10 5 , Welchs t -test), comparable to that of class III variants (A + , Mahidol and Murcia) associated with mild anaemia 34
By way of non-limiting examples, the formulations are administered as otic drops, as intratympanic injections, as foams or as otic paints
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Increasing concentrations of HQ in the presence of L-tyrosine, resulted in an increase in the K m value while the V max remained constant, an indication of a competitive inhibition mode on the monophenolase activity, with a K I of 40 M and apparent K m and V max values of 0.07 mM and 9.0 mole min 1 mg 1 , respectively (Fig