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Individuals received a condition flag if they had one or more claims/encounters that matched a respective ICD-10 code mapped onto one of the Bridge clinical criteria in an inpatient, outpatient, carrier, home health, or skilled nursing facility setting in 2023

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To control for multiple comparisons, the BenjaminiHochberg method was used to adjust the p values, and proteins with a false discovery rate (FDR) less than 0.05 were considered significant for further analysis

No human dose-finding trial exists

Keeping growth hormone elevated over time supports skin elasticity and the health of connective tissue