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Discovery and Research Timeline Researchers identified the first estrogen-related receptor as an orphan nuclear receptor related to, but distinct from, classical estrogen receptors

Accessible multiomics signatures of zinc-dependent organelle dysfunction Organelle-specific zinc imbalance produces characteristic transcriptional, proteomic and metabolomic consequences that may be detectable in accessible biospecimens such as blood, cerebrospinal fluid or urine

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2000;284:301521 [17] Fildes A, Charlton J, Rudisill C, Littlejohns P, Prevost AT, Gulliford MC

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