GP100075: MUC1(126-149-Cys)-Tn(131,144) Pack Size:1 mg The fragment contains tumor-associated carbohydrate

The fragment contains tumor-associated carbohydrate antigen (TACA)

producing high-avidity binding that substantially exceeds the affinity of monovalent GalNAc ligands and closely mimics the geometry of clinically validated Tri-GalNAc targeting moieties used in approved GalNAc-siRNA therapeutics

27 / An α-D-N-acetylgalactosamine (α-D-GalNAc) ligand equipped with an azide-functionalized linker through a short ethyl spacer

144) / Mucin1

N-α-Fmoc-O-(hepta-O-acetyl-α-D-mannopyranosyl-α(1-2)-D-mannopyranosyl)-L-threonine

GP100075: MUC1(126-149-Cys)-Tn(131,144) Pack Size:1 mg The fragment contains tumor-associated carbohydrateC114H180N32O43S 2718. 9 MUC1 synthetic glycopeptide. Glycosylated Mucin 1 (MUC1) peptide fragment containing amino acid sequence Pro126Gly149 (24 AA in length) from the tandem repeat (TR) region of the MUC1 protein. The fragment contains tumor associated carbohydrate antigen (TACA), Tn antigen, O glycosylation ( GalNAc) at Thr131 and Thr144. The C terminus Cysteine (amide) allows for conjugation to maleimide functionalized carrier proteins. MUC1(126