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doi: 10.1371/journal.pone.0046083 75 ShiQLiuYYangWLiYWangCGaoK

Metformin can not only amplify insulin sensitivity which can connect to increased proliferation and has a positive effect on dyslipidemia, and also treat skin issues like acanthosis nigricans, acne, and hirsutism [56]

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In most ferroptosis-related conditions including hepatic steatosis, cardiomyopathy, spinal cord injury, and BPA-induced liver damage, both enzymes are simultaneously upregulated, promoting lipid peroxidation and enhancing ferroptotic signaling (7073)