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It thereby reduces oxidative stress and upregulation of VDBP/CYP2R1/CYP27A1/VDR , which is required for the efficient transport and hydroxylation of cholecalciferol, and activation of the VDR/PGC-1/GLUT-4 pathway responsible for the metabolic actions of 1,25(OH) 2 VD [44]

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Eating small but frequent meals is advisable to prevent glucose spikes

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IV therapy is significantly more effective, providing 90-100% bioavailability compared to only 10-50% for oral supplements