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The most advanced example is retatrutide by Eli Lilly, according to clinical trial outcomes
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This means people start at the lowest dose and its increased over time to keep side effects to a minimum
One study explored mechanistic associations between GLP-1 functioning and mood disorders in humans: a post-mortem investigation showed that, compared with healthy controls, patients who had been diagnosed with mood disorders had lower expression of the gene encoding for GLP-1R in the dorso-lateral prefrontal cortex and the hippocampus, whereas this association was not observed in the brain tissue of people with schizophrenia 176