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Whereas peaks in steady state levels may be associated with drug adverse effects, troughs may be associated with loss of efficacy

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FIGURE 3 FIGURE 4 AQP4 Was a Functional Target Gene of miRNA-146a-3p To investigate the reason of AQP4 decreased after GHK treatment, we predict the potential target microRNAs (miRNAs) of AQP4 (Supplementary Table 1) and got intersection elements with miRNAs down-regulated in ICH patients (Zhu et al., 2015