The condition is characterized by redox imbalance and iron overload, with affected cells exhibiting smaller mitochondria, increased membrane density, and reduced cristae, while the nucleus shows minimal changes (Li J
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10.1016/j.biopha.2021.112416 20 ChenX.HeH.LongB.WeiB.YangP.HuangX.et al (2023a)
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Likewise, c-fos, a marker of neuronal activity, is increased in the NTS, where vagal afferents terminate, and in the nodose ganglia after different nutrient loads 41