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Notably, MOTS-c was shown to activate the downstream metabolic transporter GLUT4 in muscle, further promoting glucose absorption into tissues

This is a reason why mitochondria are a main target for GSH to neutralise ROS and reduce oxidative stress

Bingl et al

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It remains unclear why 5-oxoproline levels would increase markedly in serum and urine in association with chronic acetaminophen ingestion in some patients