Loss of redox balance further constrains glutathione synthesis and recycling, magnifying cellular vulnerability
Moreover, the absence of significant redox fluctuations does not necessarily disprove the hypothesis that cell cycle progression is accompanied by shifts in nuclear GSH concentration [44,45] because the total concentration of GSH could change without altering its redox potential
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May be mild compression of adjacent hepatic parenchyma
Cysteine availability is the primary bottleneck because it is maintained at much lower intracellular concentrations than glutamate or glycine
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