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Despite the early termination of the trial, it is interesting to note that 13 of 140 patients had a median duration of response of 10.2 months, indicating that these patients benefited from combination therapy and that exploring the mechanisms of this benefit should be the focus of future research

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Nevertheless, redox cycling remains an understated mechanism of toxicity due to the fleeting existence of free radical intermediates which hinders their quantification in real time, both in vitro and in vivo 6