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The topical route is the format with the strongest human clinical trial evidence for skin outcomes, from the landmark 1998 Abdulghani study that outperformed both vitamin C and tretinoin to the Finkley skin-thickness data

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Injectable application has a shorter track record, though the biological mechanisms remain identical

10.1016/j.freeradbiomed.2015.06.019 Free Radic Biol Med

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