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Consider avoiding things that increase (i.e., induce) CYP1b1 and CYP3a4 enzymatic activity Recall that CYP1b1 is the enzyme that converts estrogen to the 4-OH metabolites and CYP3a4 is the enzyme that converts estrone (E1) to the 16-OH-E1 metabolite, and estradiol (E2) to estriol (E3)

Women who are pregnant or may become pregnant must not handle crushed dutasteride capsules, and the addition of glutathione does not modify this absolute contraindication [3]

Therefore, as a result, NRF2 activator is viewed as a promising medication for boosting antioxidant defences and reducing pathology

Large human trials and better active surveillance would help answer these questions