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P., Iliescu, R

However, the lack of substrate (i.e., little incoming glucose) blunts the insulin response GIP would otherwise engender

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Youre not making enough insulin, and insulin is not working as well as it should because youre resistant to insulin

Patients should also be informed about serious gastrointestinal adverse events that require urgent medical attention, including severe persistent abdominal pain (with or without vomiting) which may indicate pancreatitis, symptoms of gallbladder disease, or signs of dehydration