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Moreover, the pattern of signal bias first demonstrated in HEK293 cells was recapitulated when we expressed SNAP-GLP-1R in INS-1 832/3 cells in which the endogenous GLP-1R was deleted by CRISPR/Cas9 (Naylor et al., 2016), with lixisenatide showing a relative preference for internalisation compared to cAMP signalling (Figure 4C, Supplementary Figure 3A)

Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats

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4 AokiM.MorishitaR.TaniyamaY.KidaI.MoriguchiA.MatsumotoK.et al (2000)