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Acetyl-CoA, derived from pyruvate, amino acids, and fatty acids, is reversibly converted to acetylcarnitine and CoA in the presence of carnitine by the carnitine acetyltransferase (CAT), a mitochondrial matrix enzyme attached to the inner membrane

2a, b, Supplementary Fig

The difference between results and disappointment comes down to understanding the synergy mechanism

This results in defects in mitophagy, whereas a large number of dysfunctional mitochondria are not removed in time and excessively accumulate in neuronal cells, which induces a vicious circle-chain reaction (Wong and Holzbaur, 2014)

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