This design choice introduces potential bias, particularly for subjective outcomes, but it reflects the practical reality that these treatments have different injection devices and titration schedules that would make blinding extremely difficult
(Medicare Advantage Plans may waive that 3 day rule)
Perovic D, Kolenc D, Bilic V, Somun N, Drmic D, Elabjer E, et al
This is true for patients with certain health issues or those who have had bad reactions
Table 2 Immune alterations present in ME/CFS and changes evident in B cells, T cells, and NK cells (99, 253255, 278, 445482)
Long-term safety beyond 12 weeks has not been formally studied in large populations