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Nature 375 : 488493

receives financial support from the Novo Nordisk Foundation (NNF23OC0081873) and the Swedish Brain Research Foundation (FO2023-0292)

Characterized by an excessive accumulation of body fat resulting from an imbalance between energy intake and expenditure, obesity constitutes a pathological condition with significant health implications

Maximum dose The maximum tirzepatide dose is typically 14 mg once weekly

Joint Pain: Paradoxically, while growth hormone is sometimes used to support joint health, it can also cause joint pain and stiffness as side effects

By integrating these mechanistic insights with emerging data on how disrupted lipid and glucose metabolism amplify immune dysregulation, the review underscores the interplay between metabolic and inflammatory pathways in exacerbating tissue injury across these organs