804 Lipid peroxide 4-HNE, which accumulates during myocardial I/R injury, promotes ubiquitination of GPX4 and induces cardiac ferroptosis by targeting the binding site of GPX4 and ovarian tumor deubiquitinase 5, while activation of aldehyde dehydrogenase 2 to degrade 4-HNE reduces myocardial ferroptosis
Improvement of elasticity and fine lines With better protection of collagen and elastin, the skin can maintain improved elasticity and resilience, making expression lines and fine wrinkles appear less pronounced
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doi: 10.1016/j.biomaterials.2025.123874
This review integrates findings from studies conducted between 2004 and 2024 to examine the impact of intermittent fasting on metabolic health, cellular mechanisms, and organ systems
52,53 Furthermore, the activation of inflammasomes mainly manifests as an elevation of serum IL-1 and interleukin-18 (IL-18) and the recruitment of inflammatory cells