Three children with available imaging at the time of diagnosis were included in the study
Effective pharmacotherapy for obesity is likely to require long-term, if not life-long, treatment, which makes it important to consider long-term adherence and weight loss efficacy, and the effects on obesity co-morbidities (particularly cardiovascular outcomes), safety (including potential adverse effects on muscle mass and bone health), and cost of poly-agonist therapy
Mutations in CPT1 can cause carnitine palmitoyltransferase I (CPT I) deficiency, which is an autosomal recessive genetic condition (need two copies of the mutation)
At our Doral clinic, the three use cases with the most clinical relevance are tendon and ligament recovery, gut-lining integrity, and systemic inflammation tied to a slow-healing injury
The mechanism is speculative (choline's role in satiety signaling, or simply feeling better and eating more mindfully)
Lai Y, Wu X, Chao E, et al