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These compounds differ in how they work, what they target, how long they stay active in the body, and what evidence exists to support their use

Chichak says

FASEB BioAdvances 2, 464477

PMID 3094341

Pooling across the field, a 2025 meta-analysis of seven randomized controlled trials, covering 456 participants, reported a standardized mean difference of -0.72 for wrinkle reduction, though the analysis noted high heterogeneity between studies and that roughly 40% of trials had industry funding both factors that warrant caution in interpreting the pooled effect size