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Metabolomic and ionomic analyses highlight the coordinated regulation of osmolyte accumulation and ionic homeostasis as a decisive determinant of tolerance, particularly under salinealkaline conditions, where ion transporter regulation must be synchronized with osmotic adjustment

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A potential mechanism of PGC-1 induction is the activation of GPR109 (G-protein coupled receptor 109, also known as hydroxycarboxylic acid receptor 2, HCA2) by its ligand HB (9092)

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