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Moreover, simultaneous inhibition of CSF1-R and the Src homology region 2 (SH2) domain phosphatase SHP-2 signaling pathway in macrophages can also effectively revert M2 macrophages to the M1 phenotype and enhance the phagocytosis of macrophages, for example, self-assembled nanoparticles (DNTs) loaded with dual inhibitors of CSF1R- and SHP2 can target M2 macrophages and cause M2 macrophages to repolarize to the M1 phenotype by simultaneously inhibiting the CSF1R and SHP2 pathways, and which has stronger phagocytosis compared to drug therapy alone, showing enhanced antitumor effects (48)

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A systematic review and meta-analysis conducted by Masarwa et al