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Elevated fumarate has been implicated in metabolic and respiratory diseases, such as airway obstruction and diabetes [83, 84]

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falciparum 3D7 Trx after incubation with 1 mM diamide, 4IC 50 of methylene blue (MB), or artemisinin (ART) for 24 h, or with 1 mM diamide, 50 mM H 2 O 2 , or 100IC 50 of MB for 15 min

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An enzyme in the small intestine called gamma-glutamyl transpeptidase (GGT) is specifically responsible for dismantling the glutathione molecule, making traditional capsules highly inefficient for raising systemic levels

SM04690 (Adavivint/Lorecivivint), a small molecule currently in Phase III clinical trials, has been formulated as SM04690@ApoF via solvent-free self-assembly into apoferritin nanocages, achieving quantifiable drug loading efficiency and sustained release equilibrium within 12 hours