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This is also the point in the night where a sleepers heart rate, blood pressure, and arousal tend to decline and, perhaps counter intuitively, when night terrors are most likely to occur

Xiao Y, Yang C, Yu L, Tian F, Wu Y, Zhao J et al (2021) Human gut-derived B

The potential molecular mechanisms underlying these effects included disturbances in redox homeostasis (as evidence by the enhanced production of ROS and reactive nitrogen species), failure of enzymatic and nonenzymatic cytoprotective mechanisms involving the glutathione system as well as nuclear factor kappa B (NF-B) and fibroblast growth factor 2-mediated pathways, and impaired mitochondrial function

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This adverse effect can be prevented by prior treatment with mesna (mercaptoethane sulphonic acid), which possesses both a thiol group for cytoprotection and a highly polar sulphonic acid group, and results in high renal excretion and delivery of this cytoprotective molecule to the bladder epithelium

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