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this effect occurs through the modulation of protein tyrosine phosphatase activity in IGF-1 signaling

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Although the existence of mtNOS has been described in mitochondrial fractions from different organs, recent evidence in rat liver mitochondria has questioned the existence of mtNOS, minimizing the contribution of in situ NO generation within mitochondrial to the formation of peroxynitrite (Venkatakrishnan et al., 2009)

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It also helps recycle other essential antioxidants, such as vitamin C and vitamin E