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Pastorello E, Stocchi L, Bigi A, Pravettoni V, Schilke ML, Valente D, & Zanussi C (1989) Value and limits of diagnostic tests in food hypersensitivity

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There is a ~ 2-hour delay in the onset of its effect because insulin is injected as a complex of insulin & protamine, and insulin is not free to become absorbed until protamine is digested by proteolytic enzymes present in body tissues

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