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Studies have identified Hexarelin's interaction with the CD36 scavenger receptor on cardiac myocytes, which activates pro-survival signaling cascades including the PI3K/Akt pathway and ERK1/2 phosphorylation, protecting cardiomyocytes from ischemia-induced apoptosis

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Although migraines are not typically classified as neurodegenerative diseases marked by extensive cell death, studies have reported the occurrence of apoptosis and pyroptosis, both forms of programmed cell death (Wang et al., 2022)

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