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Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis

The mean duration of semaglutide treatment was 28 months

semaglutide, n =21), weight and BMI were 90.5 kg (83.4, 107.9) and 34.0 kg/m 2 (31.7, 38.7), respectively, with a post-bariatric weight regain of 15.1% (10.6, 22.8) of total body weight and 4.6 kg/m 2 (3.3, 6.2)

35 Underlying Conditions: Certain conditions, notably type 2 diabetes, are associated with slightly less weight loss on these medications compared to individuals without diabetes

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Most weight loss specialists avoid this combination due to overlapping cardiovascular effects and limited safety data supporting concurrent use