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In contrast to IL-10, tumor necrosis factor induced protein 3 (TNFAIP3), also known as an anti-inflammatory protein (43), was already downregulated at 24 h and reached again the initial level at 14 d pi

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In addition, among proposed mutational drivers of esophageal cancer, the screen identified 49 genes that regulate the fitness of normal esophageal progenitor cells

However, in one study, the observed positive effect was not associated with a reduction in urinary F 2 -isoprostane levels (Efrati et al., 2003), suggesting that NACs protective action may involve mechanisms other than antioxidant activity