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The field is so far proving to be unpredictable

Shang Y, Nasr P, Widman L, et al

This multi-receptor mechanism distinguishes it from existing approved therapies such as semaglutide or tirzepatide, and it is this broad pharmacological activity that underpins both its therapeutic potential and its side effect profile

J Alzheimers Dis (2015) 46(4):87788

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A recent meta-analysis of mixed evidence (5 RCTs 52,183,184,185,186 and 1 cohort study 187 ) in 2,071 people with T2DM or Parkinsons disease suggested antidepressant efficacy of the GLP-1RAs exenatide and liraglutide over 2452 weeks 188