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BAs act in the brain by interacting with key receptors on neurons and glial cells-Farnesoid X receptor (FXR), Takeda G protein receptor 5 (TGR5), GR, and sphingosine-1-phosphate receptor 2 (S1PR2

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2024ZR015 by YH, No

The specific mechanism may involve a compromised intestinal barrier allowing antigens from the gut microbiota to penetrate and contact IgG antibodies, forming immune complexes that circulate in the bloodstream, including to the choroid plexus of the CNS