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Krassas, L

The use of lipoic acid is currently approved for the treatment of diabetic neuropathy in Germany (4)

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N-acetylcysteine (NAC) is the most well-known precursor

Clin Biochem 42(1314):13681374 Kurutas EB (2016) The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

The D-retro-inverso design replaces all L-amino acids with D-amino acids and reverses the sequence a structural strategy that preserves the side-chain topology of the original FOXO4 binding region while making the peptide resistant to proteolytic degradation, dramatically extending plasma half-life compared to the natural L-form