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Additionally, to explore the therapeutic potential of ROS homeostasis modulation in disease treatment, this review comprehensively summarizes existing drugs and intervention strategies targeting ROS hemeostasis, while also exploring emerging therapeutic approaches

Researchers found that GLP-1 receptor agonism significantly reduces Cyp2e1 expression in animal models, with reductions of 40-60% observed

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The proposed direct vascular mechanisms, supported by preclinical and clinical data, include the following: Endothelial protection: GLP-1 receptor agonists promote nitric oxide production, vasodilation, and angiogenesis while inhibiting oxidative stress in vascular endothelial cells Plaque stabilization: Reduced matrix metalloproteinase activity prevents fibrous cap degradation

PHEN/TPM should be used cautiously in older adults taking hypertension or rate-controlling agents

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