doi: 10.1172/jci.insight.169515 119 ChandraAWormserGPKlempnerMSTrevinoRPCrowMKLatovNet al
Arthritis Rheum 56:24454, PMID: 17195228 Gravina P, Spoletini I, Masini S, Valentini A, Vanni D, Paladini E, Bossu P, Caltagirone C, Federici G, Spalletta G, Bernardini S (2011) Genetic polymorphisms of glutathione S -transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia
Its primary purpose is to neutralize free radicals by offering them an oxygen molecule, thereby protecting cells from damage
Progressive glutathione depletion across trimesters : First trimester: 36% LOWER than non-pregnant Second trimester: 55% LOWER Third trimester: 87% LOWER This generates more NAPQI at precisely the time when glutathione reserves are least able to neutralize itcreating maximum vulnerability
Figure 3 shows no significant alteration in the docked compounds conformation after 100 ns MD simulation in reference to initial poses, suggesting that docked ligands maintained the strong interactions with essential residues in the catalytic pocket during MD simulation interval and established the formation of stable complexes
Biotechnol Bioeng 117(5):14261435
