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Vitamin B5 (pantothenic acid) is a component of coenzyme A, crucial for numerous metabolic pathways and the proper functioning of the citric acid cycle

In parallel, ferroptosis suppressor protein 1 (FSP1)/ubiquinol (CoQH2), dihydroorotate dehydrogenase/CoQH2 and GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin have been identified as independent systems that scavenge free radicals to exert their antioxidative effects and suppress ferroptosis (17-21)

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10 Likewise, in females, excess ROS can directly cause damage to the oocytes and is implicated in a number of conditions linked to fertility such as polycystic ovarian syndrome and endometriosis

The presence of chronic hyperglycemia, insulin resistance, oxidative stress, and pro-inflammatory mechanisms contribute to endothelial dysfunction in patients with diabetes mellitus (61)

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