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People with type 2 diabetes who have already maximized one medication class and still fall short of HbA1c targets particularly show dramatic response to adding a complementary agent

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Ultimately, these are scientifically supported and highly bioavailable

Concomitant use of saxagliptin and metformin hydrochloride extended-release tablets with insulin or an insulin secretagogue may require lower dosages of insulin or the insulin secretagogue to reduce the risk of hypoglycemia [see Warnings and Precautions (5.5)]

Often the first move is to slow the dose-escalation rather than stop the drug entirely