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The stage of hepatic fibrosis predicts both overall and liver-related mortality and is the strongest predictor of long-term clinical outcomes, with advanced fibrosis (stages 3 and 4) conveying the highest risk of mortality [6]

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Among these enzyme systems, choline-TMA lyase and carnitine monooxygenase are the key enzymes (Rath et al., 2017), which are the targets for reducing TMAO concentrations

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