These sex-specific pathways are an active research area and are why lab-guided GLP-1 selection matters considerably more than defaulting to whatever a friend is taking
A side-plate-sized meal is a good place to start
Because of its truncated structure, it is highly resistant to acidic environments
Other potential long-term complications include: Decreased lung function Depression due to slower mental functioning An abnormal enlargement of the thyroid gland (goiter) Heart issues, including high cholesterol and heart disease Infertility in women, due to the inability to ovulate from lack of thyroid hormones Inability to lose weight Nerve damage in the arms, legs, and feet (peripheral neuropathy) Delayed physical and intellectual development in babies born to mothers who are hypothyroid Delayed development in children with untreated hypothyroidism Myxedema coma (in rare cases), when the bodys level of thyroid hormone becomes extremely low What Is Myxedema, or Advanced Hypothyroidism
It is currently completing Phase 3 TRIUMPH trials and is available for research use in lyophilized (freeze-dried powder) form for the latest on [when retatrutide will be FDA approved](/guides/retatrutide-fda-approval-2026-timeline-status), see our regulatory timeline tracker
In the US alone, approximately $72 billion was spent last year on GLP-1 therapies
