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Two residues with shorter side chains (I7 P and A13 P ) in GIP further weakened its binding to GLP-1R, consistent with the distinct cross-reactivity features of GIP and GCG with GLP-1R 5,6
Mean weight loss at six months was 11.5kg
Week 1: Start at 25% of the target dose, once daily
Serious adverse effects requiring monitoring include: Hypoglycemia : While GLP-1 receptor agonists have low intrinsic hypoglycemia risk due to glucose-dependent mechanisms, risk increases with concomitant insulin or sulfonylurea use
This focused investigation should provide detailed electrocardiographic data, ambulatory monitoring results, and potentially echocardiographic measurements that will clarify whether the heart rate and contractility changes translate into any structural or functional cardiac concerns
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