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By contrast, biomarkers that directly reflect the level of neuronal activity and real-time drug-induced changes in this activity offer superior tools for therapeutic evaluation

The analysis included 72 participants with a diagnosis of MDD and a body mass index 25 kg/m2 who were randomly assigned to oral semaglutide (35 individuals) or placebo (37 individuals).The researchers found that semaglutide-treated participants showed a pattern of increased willingness to exert physical efforts with higher expected values of reward (treatment visit expected value interaction: 2 = 12.024)

*Correspondence: Amjad Khan, [email protected]

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Explaining the physiology helps patients separate their achievement from its aesthetic side effects