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however, this theory has been called into question as APAP-protein adducts have been detected at 1 hour after APAP treatment, a time that that would precede GSH depletion.8 It is important to note, however, that a clear inverse relationship has been demonstrated between GSH concentration and APAP metabolic activation activity.8 Findings from current studies of APAP hepatotoxicity seem to favor the mechanism of toxic injury being related to mitochondrial and endoplasmic reticula leading to hepatocyte injury and necrosis

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