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O-glycosylation (NeuAcα2-6GalNAc) at Thr131 and Thr144
/ α-L-Rha-Ethyl-Azide / α-Rha-Et-N3
Fmoc-L-Ser(Glc(Ac)4-β-D)-OH
Fmoc-Ser(β-D-Cel(Ac)7)-OH
The terminal amine is protected with a benzyloxycarbonyl (Cbz) group
AG542000: β-D-Glc-Butyl-Carboxylic Acid Pack Size:50 mg O-glycosylation (NeuAcα2-6GalNAc) at Thr131 andC11H20O8 280. 27 A D glucose ligand equipped with a terminal carboxylic acid through a short butyl spacer. The carboxylic acid can be activated to NHS, sulfo NHS, or pentafluorophenyl (PFP) esters and reacted with amine functionalized platforms or lysine residues on proteins and peptides to form stable amide bonds. This compound provides a D glucose building block for glycoconjugate synthesis, glycomimetic research, and the construction of probes for
