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Retatrutide Development History: Discovery to Phase 3 Retatrutide was designed at Eli Lilly around 2016-2018 and first tested in humans in 2019

To assess the associations of semaglutide with recurrent AUD, the study population comprised 22,113 patients who had active medical encounters for T2DM diagnosis in 12/20175/2021, were for the first time prescribed semaglutide or non-GLP1-1RA anti-diabetes medications during 12/20175/2021(index event), had a diagnosis of AUD on or before the index event, and had a diagnosis of at least one of obesity-associated comorbidities on or before the index event

Dehydration can be particularly dangerous for patients with diabetes, as it may precipitate acute kidney injury or diabetic ketoacidosis

Severe dehydration can lead to kidney strain

Together, you can decide whether its the right time or whether continuing treatment may help you maintain your progress

But two specific trials pointed beyond safety to active benefit